Mandible and maxilla bone mineral density and threshold analysis studies by pQCT in two edentulous women receiving pamidronate.
Identifieur interne : 007C75 ( Main/Exploration ); précédent : 007C74; suivant : 007C76Mandible and maxilla bone mineral density and threshold analysis studies by pQCT in two edentulous women receiving pamidronate.
Auteurs : Victor E. Montangero [Argentine] ; Ricardo Capiglioni ; Emilio J A. RoldánSource :
- Cranio : the journal of craniomandibular practice [ 0886-9634 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Calcification physiologique (), Densité osseuse (), Diphosphonates (usage thérapeutique), Déminéralisation osseuse pathologique (imagerie diagnostique), Déminéralisation osseuse pathologique (traitement médicamenteux), Femelle, Humains, Maladies osseuses métaboliques (imagerie diagnostique), Maladies osseuses métaboliques (traitement médicamenteux), Mandibule (), Mandibule (imagerie diagnostique), Maxillaire (), Maxillaire (imagerie diagnostique), Moelle osseuse (), Moelle osseuse (imagerie diagnostique), Mâchoire partiellement édentée (imagerie diagnostique), Mâchoire partiellement édentée (physiopathologie), Mâchoire édentée (imagerie diagnostique), Mâchoire édentée (physiopathologie), Tomodensitométrie, Traitement d'image par ordinateur.
- MESH :
- imagerie diagnostique : Déminéralisation osseuse pathologique, Maladies osseuses métaboliques, Mandibule, Maxillaire, Moelle osseuse, Mâchoire partiellement édentée, Mâchoire édentée.
- physiopathologie : Mâchoire partiellement édentée, Mâchoire édentée.
- traitement médicamenteux : Déminéralisation osseuse pathologique, Maladies osseuses métaboliques.
- usage thérapeutique : Diphosphonates.
- Adulte d'âge moyen, Calcification physiologique, Densité osseuse, Femelle, Humains, Mandibule, Maxillaire, Moelle osseuse, Tomodensitométrie, Traitement d'image par ordinateur.
English descriptors
- KwdEn :
- Bone Demineralization, Pathologic (diagnostic imaging), Bone Demineralization, Pathologic (drug therapy), Bone Density (drug effects), Bone Diseases, Metabolic (diagnostic imaging), Bone Diseases, Metabolic (drug therapy), Bone Marrow (diagnostic imaging), Bone Marrow (drug effects), Calcification, Physiologic (drug effects), Diphosphonates (therapeutic use), Female, Humans, Image Processing, Computer-Assisted, Jaw, Edentulous (diagnostic imaging), Jaw, Edentulous (physiopathology), Jaw, Edentulous, Partially (diagnostic imaging), Jaw, Edentulous, Partially (physiopathology), Mandible (diagnostic imaging), Mandible (drug effects), Maxilla (diagnostic imaging), Maxilla (drug effects), Middle Aged, Tomography, X-Ray Computed.
- MESH :
- chemical , therapeutic use : Diphosphonates.
- diagnostic imaging : Bone Demineralization, Pathologic, Bone Diseases, Metabolic, Bone Marrow, Jaw, Edentulous, Jaw, Edentulous, Partially, Mandible, Maxilla.
- drug effects : Bone Density, Bone Marrow, Calcification, Physiologic, Mandible, Maxilla.
- drug therapy : Bone Demineralization, Pathologic, Bone Diseases, Metabolic.
- physiopathology : Jaw, Edentulous, Jaw, Edentulous, Partially.
- Female, Humans, Image Processing, Computer-Assisted, Middle Aged, Tomography, X-Ray Computed.
Abstract
The mandible and maxilla of two edentulous women, treated during 25 weeks with oral pamidronate, were monitored by peripheral quantitative tomography (pQCT). Whole bone volumetric mineral density failed to show meaningful variations after treatment. However, an analysis of separated cortical and medullar areas disclosed focal bone loss at the right mandible cortex of patient #1 and at the left maxilla cortex of patient #2. These and other bone sub-regions were further studied by clustering the internal sites with a different degree of bone mineral density, resorting to the mineral threshold analysis provided by the system. Where bone loss was detected, it corresponded to increased loss of the most osteopenic sites, while medium and high-density portions tended to remain unchanged within the region. There were no significant variations in all other regions, or alternatively, minor losses at osteopenic sites were compensated by an increase at high-density portions. Hence, the pQCT system allowed monitoring volumetric bone mineral density at particular sites of interest, discriminating variations at portions with a dissimilar degree of bone volume. Further studies should confirm whether pamidronate exerts a protective effect on sub-regions with previous medium and high degrees of bone mineralization, as suggested by our present findings.
PubMed: 12723856
Affiliations:
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Le document en format XML
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Whole bone volumetric mineral density failed to show meaningful variations after treatment. However, an analysis of separated cortical and medullar areas disclosed focal bone loss at the right mandible cortex of patient #1 and at the left maxilla cortex of patient #2. These and other bone sub-regions were further studied by clustering the internal sites with a different degree of bone mineral density, resorting to the mineral threshold analysis provided by the system. Where bone loss was detected, it corresponded to increased loss of the most osteopenic sites, while medium and high-density portions tended to remain unchanged within the region. There were no significant variations in all other regions, or alternatively, minor losses at osteopenic sites were compensated by an increase at high-density portions. Hence, the pQCT system allowed monitoring volumetric bone mineral density at particular sites of interest, discriminating variations at portions with a dissimilar degree of bone volume. Further studies should confirm whether pamidronate exerts a protective effect on sub-regions with previous medium and high degrees of bone mineralization, as suggested by our present findings.</div></front></TEI><affiliations><list><country><li>Argentine</li></country></list><tree><noCountry><name sortKey="Capiglioni, Ricardo" sort="Capiglioni, Ricardo" uniqKey="Capiglioni R" first="Ricardo" last="Capiglioni">Ricardo Capiglioni</name><name sortKey="Roldan, Emilio J A" sort="Roldan, Emilio J A" uniqKey="Roldan E" first="Emilio J A" last="Roldán">Emilio J A. Roldán</name></noCountry><country name="Argentine"><noRegion><name sortKey="Montangero, Victor E" sort="Montangero, Victor E" uniqKey="Montangero V" first="Victor E" last="Montangero">Victor E. 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